Galactosaminogalactan of Aspergillus fumigatus, a bioactive fungal polymer.
نویسندگان
چکیده
Galactosaminogalactan (GAG) is an extracellular polysaccharide produced by the mycelium of the opportunistic human fungal pathogen Aspergillus fumigatus GAG is the first polysaccharide described as a virulence factor in medical mycology. This review presents our current knowledge of the structural organization and biosynthesis of this polymer. The function of this molecule as an adhesin that also masks Aspergillus PAMPs and the impact of GAG on the modulation of the host immune response by inducing neutropenia and blocking the IL-1 signaling pathway also will be emphasised.
منابع مشابه
Galactosaminogalactan, a New Immunosuppressive Polysaccharide of Aspergillus fumigatus
A new polysaccharide secreted by the human opportunistic fungal pathogen Aspergillus fumigatus has been characterized. Carbohydrate analysis using specific chemical degradations, mass spectrometry, ¹H and ¹³C nuclear magnetic resonance showed that this polysaccharide is a linear heterogeneous galactosaminogalactan composed of α1-4 linked galactose and α1-4 linked N-acetylgalactosamine residues ...
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ورودعنوان ژورنال:
- Mycologia
دوره 108 3 شماره
صفحات -
تاریخ انتشار 2016